For Health Care Professionals Outside the US

 
 
 

FARYDAK® oral dosing: 3 times a week, 2 weeks on, 1 week off1

FARYDAK® (panobinostat) is available in 3 strengths for dosing flexibility1

FARYDAK should be administered orally once daily on scheduled days only, at the same time each day. The capsules should be swallowed whole with water, with or without food, and they should not be opened, crushed or chewed. If a dose is missed, it can be taken up to 12 hours after the specified dose time. If vomiting occurs the patient should not take an additional dose, but should take the next usual prescribed dose.1

Consistent dosing schedule of FARYDAK in all cycles of treatment1

  • FARYDAK is given in combination with BTZ and dex1
    • Patients should be treated initially for eight 3-week cycles
    • Patients with a clinical benefit should continue treatment for 8 additional cycles
  • Treatment dose and/or schedule modification may be required based on individual tolerability1
    • If dose reduction is required, the dose should be adjusted by decrements of 5 mg. The dose should not be reduced below 10 mg and the same treatment schedule should be kept
    • No dose adjustment is needed in patients with renal impairment
    • Patients with hepatic impairment should be started at a modified dose
    • For patients >65 years of age, monitoring is recommended more frequently, especially for thrombocytopenia and gastrointestinal toxicity
    • For patients >75 years of age, depending on the patient’s general condition and concomitant diseases, an adjustment of the starting doses or schedule of the components of the combination regimen may be considered
  • In patients who take concomitant medicinal products that are strong CYP3A and/or Pgp inhibitors, the dose should be reduced to 10 mg1

BTZ and dex prescribing information should be consulted prior to the start of the combination treatment to assess whether a dose reduction is required.

Reference:

  1. FARYDAK® (panobinostat). EU Summary of Product Characteristics. Novartis AG; August 2015.

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